Search results for "Pulmonary Surfactant-Associated Protein D"

showing 7 items of 7 documents

Serum surfactant protein D and exhaled nitric oxide as biomarkers of early lung damage in systemic sclerosis

2017

Background Interstitial lung disease (ILD) complicates the course of systemic sclerosis (SSc), representing the main cause of death in these patients. The identification of parameters that can predict the early onset and progression of ILD in SSc represents an unmet need in clinical practice. The study was designed to explore whether the surfactant proteins (SP) A and D may be used as noninvasive tools for the early identification of ILD in SSc. Alveolar exhaled nitric oxide (NO) was investigated as a surrogate marker of distal inflammation. Methods Unselected consecutive subjects newly diagnosed with scleroderma and subjects free of respiratory and systemic diseases were recruited. All pat…

AdultMalemedicine.medical_specialtyBreath TestSettore MED/10 - Malattie Dell'Apparato RespiratorioGastroenterologySclerodermaScleroderma03 medical and health sciencesFEV1/FVC ratio0302 clinical medicineDLCOInternal medicineMedicineHumansRespiratory systemLungScleroderma Systemicbusiness.industryPulmonary surfactant-associated proteinMedicine (all)SystemicInterstitial lung diseaseSurfactant protein DNitric oxideGeneral MedicineBiomarkerrespiratory systemmedicine.diseasePulmonary Surfactant-Associated Protein Dmedicine.anatomical_structure030228 respiratory systemBreath Tests030220 oncology & carcinogenesisLung diseaseExhaled nitric oxideFemalebusinessInterstitialLung Diseases InterstitialBiomarkersHuman
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The potential role of SP-D as an early biomarker of severity of asthma

2021

Surfactant decreases the surface tension of peripheral airways and modulates the immunological responses of the lung. The alterations of surfactant due to the airway inflammation suggest a role in the pathogenesis of asthma. We aim to test the hypothesis that serum levels of SP-A (Surfactant Protein A) and SP-D (Surfactant Protein-D) are altered in patients with mild asthma compared to healthy controls and those alterations are related to functional abnormalities of peripheral airways, which are an early marker of progression of asthma. In this pilot study, we recruited 20 mild asthmatics and 10 healthy controls. We measured serum SP-A and SP-D and all subjects underwent clinical, lung func…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyprecision medicinePilot ProjectsSettore MED/10 - Malattie Dell'Apparato RespiratorioGastroenterologyPathogenesisPulmonary surfactantInternal medicinemedicineHumansIn patientAsthmasmall airwaysLungbusiness.industryasthmaPulmonary Surfactant-Associated Protein Dmedicine.diseaserespiratory tract diseasesPeripheralSurfactant protein Amedicine.anatomical_structureBreath TestsBiomarker (medicine)businessBiomarkersJournal of Breath Research
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Pathological significance and prognostic value of surfactant protein D in cancer

2018

Surfactant protein D (SP-D) is a pattern recognition molecule belonging to the Collectin (collagen-containing C-type lectin) family that has pulmonary as well as extra-pulmonary existence. In the lungs, it is a well-established opsonin that can agglutinate a range of microbes, and enhance their clearance via phagocytosis and super-oxidative burst. It can interfere with allergen–IgE interaction and suppress basophil and mast cell activation. However, it is now becoming evident that SP-D is likely to be an innate immune surveillance molecule against tumor development. SP-D has been shown to induce apoptosis in sensitized eosinophils derived from allergic patients and a leukemic cell line via …

Male0301 basic medicineLung NeoplasmsDatasets as Topic0302 clinical medicineEpidermal growth factorNeoplasmsImmunology and AllergyRNA NeoplasmOriginal ResearchCancerOvarian NeoplasmsInnate immunitySurfactant protein DBioinformatics analysiPrognosisPulmonary Surfactant-Associated Protein DImmunohistochemistryTumor microenvironment030220 oncology & carcinogenesisAdenocarcinomaFemaleCancersBreast NeoplasmHumanlcsh:Immunologic diseases. AllergyPrognosiImmunologyBreast NeoplasmsBiology03 medical and health sciencesImmune systemBioinformatics analysisStomach NeoplasmsStomach NeoplasmBiomarkers TumormedicineHumansComputer SimulationLung cancerTumor microenvironmentOvarian NeoplasmComputational BiologySurfactant protein DCancermedicine.diseaseSurvival AnalysisLung NeoplasmImmune surveillance030104 developmental biologyCancer researchNeoplasmBioinformatics analysis; Cancers; Immune surveillance; Immunohistochemistry; Innate immunity; Surfactant protein D; Tumor microenvironment; Immunology and Allergy; Immunologylcsh:RC581-607Ovarian cancer
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Serum Surfactant Protein D as a Marker of Asthma Severity

2016

Pulmonary and Respiratory MedicinePulmonary Surfactant-Associated Protein Abusiness.industryAsthma severitySurfactant protein DBiomarkerSettore MED/10 - Malattie Dell'Apparato Respiratoriomedicine.diseasePulmonary Surfactant-Associated Protein DCritical Care and Intensive Care MedicineAsthma03 medical and health sciences0302 clinical medicine030228 respiratory systemImmunologyMedicineHumans030212 general & internal medicinePulmonary Surfactant-Associated Protein DbusinessCardiology and Cardiovascular MedicineBiomarkersAsthmaPulmonary Surfactant-Associated Protein AHuman
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Hyaluronic Acid Present in the Tumor Microenvironment Can Negate the Pro-apototic Effect of a Recombinant Fragment of Human Surfactant Protein D on B…

2020

Copyright © 2020 Murugaiah, Agostinis, Varghese, Belmonte, Vieni, Alaql, Alrokayan, Khan, Kaur, Roberts, Madan, Bulla and Kishore. Human surfactant protein D (SP-D) belongs to the family of collectins that is composed of a characteristic amino-terminal collagenous region and a carboxy-terminal C-type lectin domain. Being present at the mucosal surfaces, SP-D acts as is a potent innate immune molecule and offers protection against non-self and altered self-such as pathogens, allergens, and tumour. Here, we examined the effect of a recombinant fragment of human SP-D (rfhSP-D) on a range of breast cancer lines. Breast cancer has four molecular subtypes characterised by varied expression of oes…

lcsh:Immunologic diseases. Allergy0301 basic medicinesurfactant protein DImmunologyCollectinApoptosisBreast Neoplasms03 medical and health sciencesbreast cancer0302 clinical medicineEpidermal growth factorCell Line Tumorhyaluronic acidTumor MicroenvironmentHumansImmunology and Allergyskin and connective tissue diseasesinnate immunityOriginal ResearchTumor microenvironmentChemistryimmune surveillanceIntrinsic apoptosisCell cyclePulmonary Surfactant-Associated Protein DRecombinant Proteins030104 developmental biologyApoptosisCell cultureSKBR3Cancer researchFemalelcsh:RC581-607030215 immunologyFrontiers in Immunology
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Genetic variations of the bitter taste receptor TAS2R38 are associated with obesity and impact on single immune traits

2015

Scope: Changes in genetic variations affecting the taste receptor, type 2, member 38 (TAS2R38) may identify the interacting mechanism leading to obesity and potential associations with proteins partaking in innate immunity, such as surfactant protein D (SPD) and mannan-binding lectin (MBL). Methods and results: We evaluated haplotypes of the bitter-taste receptor TAS2R38 in an identification sample of 210 women in different weight conditions, including anorexia nervosa and obesity. The association with SPD and MBL was tested in an independent sample picturing general population (n = 534). The relationship with obesity was validated in an extended final sample of 1319 participants. In the sa…

AdultMale0301 basic medicinemedicine.medical_specialtyAdolescentPopulation030209 endocrinology & metabolismSingle-nucleotide polymorphismBiologyMannose-Binding LectinPolymorphism Single NucleotideBody Mass IndexReceptors G-Protein-CoupledCohort StudiesYoung Adult03 medical and health sciences0302 clinical medicineInternal medicinemental disordersGenetic variationmedicineHumansObesityeducationAgedGeneticseducation.field_of_study030109 nutrition & dieteticsBody WeightSmokingHaplotypeGPR120Middle AgedPulmonary Surfactant-Associated Protein Dmedicine.diseaseObesityImmunity InnateTAS2R38EndocrinologyHaplotypesAnorexia nervosa (differential diagnoses)Case-Control StudiesTasteFemaleFood ScienceBiotechnologyMolecular Nutrition & Food Research
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Asthmatics with high levels of serum surfactant protein D have more severe disease.

2016

Pulmonary surfactant is a mixture of lipids and surfactant-specific proteins that covers the alveolar surface, as well as the terminal conducting airways, lowering the surface tension at the air–liquid interface during breathing. The involvement of pulmonary surfactant in the pathophysiology of asthma has been suggested. An interesting working hypothesis is that the surface tension of the peripheral airways is altered in asthma, because the inflammatory process affects the structure and function of surfactant, leading to excessive airway narrowing and features of air trapping. We explored whether serum levels of surfactant protein D (SP-D) in asthmatics are related to the severity of the di…

0301 basic medicinePulmonary and Respiratory MedicineAdultMalesurfactantStatistics as TopicSevere diseasemacromolecular substancesSettore MED/10 - Malattie Dell'Apparato RespiratorioSeverity of Illness Index03 medical and health sciences0302 clinical medicineSeverity of illnessMedicineHumansAnti-Asthmatic Agentsbusiness.industrySmall airwaysSurfactant protein DReproducibility of Resultsrespiratory systemMiddle AgedPulmonary Surfactant-Associated Protein DAsthmaRespiratory Function Tests030104 developmental biology030228 respiratory systemImmunologyBiomarker (medicine)FemalebusinessBiomarkersThe European respiratory journal
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